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发布于:2018-1-4 05:59:16  访问:4 次 回复:0 篇
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Cells (T98G, U87) as a model system, the contents of
Hill2 and Jonathan CebonThe Ludwig Institute for Cancer Study, Heidelberg, Australia; Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia2P7B-Dendrogenin A promotes secretion of anti-tumour exosomes from aggressive melanoma cells Carayon Kevin1, Poirot Marc1, de Medina Philippe2, Payre Bruno1, Sandrine Silvente-Poirot#1 and Michel Record#1 CRCT Team ``Sterol Metabolism and Therapeutic Innovations in Oncology‘‘, Toulouse, France; 2Affichem, Canal Biotech 1, Toulouse, France # Co-authors, InsermIntroduction: Dendrogenin A (DDA) was identified as a all-natural metabolite Ravoxertinib chemical information derived from cholesterol that induces in vitro and in vivo differentiation and death of a variety of tumour cells (de Medina et al., J Med Chem. Methods: Secreted vesicles isolated from DDA- and vehicle-treated melanoma cells for 24 h had been analysed for their size, density and exosomal markers as well as markers linked with melanoma differentiation and exosome biogenesis. Results: Our data established that DDA-secreted vesicles have been exosomes. Tetraspanins were found in equal quantity in DDA and manage exosomes. In contrast, the levels of heat-shock.Cells (T98G, U87) as a model system, the contents of exosomes harvested 24 h immediately after exposure to an absorbed dose of 8 Gy of 137Cs gamma rays are getting studied. Liquid chromatography andCitation: Journal of Extracellular Vesicles 2014, 3: 24214 - http://dx.doi.org/10.3402/jev.v3.Scientific Plan 2014 ISEV meetingmass spectrometry are being utilised to examine exosomes made by irradiated cells to these developed by sham-treated cells. The effect of exosomes shed in the irradiated tumour cells on the induction of stressful effects in recipient bystander cells will be examined using cells usually present within the glioma microenvironment (standard astrocytes, microglia and neural stem cells). Outcomes: Data will probably be presented on survival, induction of DNA harm, modulation of stress-inducible signalling pathways, and activation and differentiation of recipient bystander cells. Depending on proteomic analysis, and guided jir.2014.0227 by data inside the literature, the effect of candidate molecules contained in exosomes jir.2013.0113 that might be implicated inside a bystander response will probably be explored. Summary/conclusion: Collectively, these results will proffer potential mechanisms for the degenerative effects that arise following cancer radiotherapy and may lead to formulation of novel protective techniques.P7B-Oncogenic PML-RARa regulates biological activity of extracellular vesicles made by leukaemic cells Yi Fang, Delphine Garnier, Tae Hoon Lee, Esterina D‘Asti, Nathalie Magnus, Brian Meehan, Laura Montermini and Janusz RakThe Investigation Institute in the McGill University Wellness Center in the Montreal Children‘s Hospital, Montreal, CanadaP7B-282=OP1-Exosomes mediate drug resistance in melanoma Laura Vella1, Bradley Coleman2, Andreas Behren1, Lesley Cheng2, Robyn Sharples2, Andrew F. Hill2 and Jonathan CebonThe Ludwig Institute for Cancer Investigation, Heidelberg, Australia; Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia2P7B-Dendrogenin A promotes secretion of anti-tumour exosomes from aggressive melanoma cells Carayon Kevin1, Poirot Marc1, de Medina Philippe2, Payre Bruno1, Sandrine Silvente-Poirot#1 and Michel Record#1 CRCT Team ``Sterol Metabolism and Therapeutic Innovations in Oncology‘‘, Toulouse, France; 2Affichem, Canal Biotech 1, Toulouse, France # Co-authors, InsermIntroduction: Dendrogenin A (DDA) was identified as a organic metabolite derived from cholesterol that induces in vitro and in vivo differentiation and death of different tumour cells (de Medina et al., J Med Chem.
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